Research lines

Saliva as a diagnostic fluid

This part of our research involves the exploration of the diagnostic value of saliva using peptide based diagnostic tools. For example, we have developed highly specific bacterial protease substrates for the detection of periopathogens and halitosis.

Antimicrobial Peptides

Saliva harbors a number of antimicrobial systems. Using antimicrobial peptides that naturally occur in saliva as lead compound we have developed a series of antimicrobial peptides with increased antimicrobial activity and low toxicity.

Wound healing properties of saliva

We were the first to identify the constituents in saliva (the salivary peptide histatin) that are responsible for its wound healing properties. Based on these natural histatin, we have developed a cyclic variant, which exhibits activity at 100 to 1000-fold lower concentration. Currently we explore the mode of action of these peptides, and the clinical applicability.

Development of protective coatings

The aim of this research topic is to develop formulations/compounds that protect oral hard and soft tissues against microbial and chemical damage. We have identified a class of naturally occurring lipids, which adhere to oral hard surfaces. These lipid layers protect the underlying surface against acidic attacks as well as bacterial adherence. In the soluble phase these lipids exert potent antimicrobial activity against a wide variety of bacterial species.